David Mendoza: Protein and Carbs

October 5th, 2008

More protein in our diet is good for us, says one of the country’s top diabetes researchers, Osama Hamdy, MD and PhD. He is the medical director of the obesity clinical program at Joslin Diabetes Center in Boston.

But whether you are a vegetarian or not protein still presents problems.

He spoke about “Higher Levels of Protein Intake are Good” at the American Diabetes Association’s June annual meeting in San Francisco, as I previously reported here. Since then, he has posted his slides for that presentation online.

We got to know each other in San Francisco and have been in touch by email.  And we just got another chance to talk about his protein concerns.

On one hand, vegetable protein is better for us than animal protein, Dr. Hamdy told me when I called him yesterday. Amino acids are the key.

The building blocks of protein are amino acids. Our cells use 20 standard amino acids.

Scientists call some of these amino acids the essential ones. They aren’t essential because they are more important than the others. They are essential because our bodies don’t synthesize them, so we have to include them in our diet.

All of us require eight of them: phenylalanine, valine, threonine, tryptophan, isoleucine, methionine, leucine, and lysine.  In addition, four more are essential in the diet of infants and growing children.

But most animal protein has a lot of two of these amino acids, lycine and valine, Dr. Hamdy says. Too much of these amino acids are hard on our kidneys. They can cause cause too much pressure inside the kidneys and the blood vessels in the kidneys to expand.

So maybe all should become vegetarians? I asked Dr. Hamdy that.

Actually, vegetarians have protein problems of their own, he says. But different problems than those facing meat-eaters.

The problem with vegetable protein is the opposite of that meat-eaters have. Rather than too much of two amino acids, vegetable protein has too little of several of them.

Which amino acids? When I pressed Dr. Hamdy to specify them, he demurred. He didn’t want to get technical. “Several of them,” he replied.

Then, what should vegetarians do? If they are committed to remaining completely vegetarian for religious, ethical, or other reasons, they need to take “ketoanalog amino acid supplements.”

Better, he implied would be to supplement their diet with that animal protein that doesn’t cause kidney problems. This is the protein that we get from dairy, egg whites, or fish.

For me this was good news. I get most of my protein from my usual breakfast of two poached egg whites and my lunch or dinner of strained yogurt and fish, particularly salmon and sardines, which are among the best sources of omega 3 fatty acids.

But Dr. Hamdy’s advice also encourages me to get more of the protein I need from vegetarian sources. Many soy-based foods are among the best sources of protein. Spinach surprised me by being one of the foods with the most grams of protein per 100 calories. If you have no gluten intolerance, seitan is a protein-rich and tasty food.

Since Dr. Hamdy is a leading advocate of a higher protein diet, I had to ask him about the Why WAIT program of which he is the principle investigator. This Weight Achievement and Intensive Treatment Program is the world’s first clinical practice program designed to help patients with diabetes lose weight through a novel multidisciplinary approach.

He is the lead author of “The Why WAIT Program: Improving Clinical Outcomes Through Weight Management in Type 2 Diabetes,” which  Current Diabetes Reports will publish in its October 2008 issue. The abstract is online.

He is also the lead author of “Why WAIT Program: A Novel Model for Diabetes Weight Management in Routine Clinical Practice,” which the journal Obesity Management just published in its August 2008 issue. The citation is online. The study shows that people with type 2 diabetes enrolled in the program lost on average 23.5 pounds — or 9.8 percent of their initial body weight — during the 12-week program.

Why, I asked, did participants in that program get 40 percent of their daily caloric intake from carbohydrates? They developed those meal plans according to the Joslin Nutrition Guidelines for obese patients with diabetes, he told me.

At the same time he indicated his preference for a lower carbohydrate diet. “The American medical establishment is awfully conservative.”

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FROM THE BEGINING…

October 4th, 2008

Do you have diabetes? Are you struggling to live with diabetes? Are you looking for information online about diabetes? Are you unsure as to what types of foods you should now be eating to help keep a check on your glucose levels? If you have answered yes to any of these questions this article may well be of interest and benefit to you.

Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. The cause of diabetes continues to be a mystery, although both genetics and environmental factors such as obesity and lack of exercise appear to play roles.

There are 20.8 million children and adults in the United States, or 7% of the population, who have diabetes. While an estimated 14.6 million have been diagnosed with diabetes, unfortunately, 6.2 million people (or nearly one-third) are unaware that they have the disease.

In order to determine whether or not a patient has pre-diabetes or diabetes, health care providers conduct a Fasting Plasma Glucose Test (FPG) or an Oral Glucose Tolerance Test (OGTT). Either test can be used to diagnose pre-diabetes or diabetes.

With the FPG test, a fasting blood glucose level between 100 and 125 mg/dl signals pre-diabetes. A person with a fasting blood glucose level of 126 mg/dl or higher has diabetes.

In the OGTT test, a person’s blood glucose level is measured after a fast and two hours after drinking a glucose-rich beverage. If the two-hour blood glucose level is between 140 and 199 mg/dl, the person tested has pre-diabetes. If the two-hour blood glucose level is at 200 mg/dl or higher, the person tested has diabetes.

Major Types of Diabetes

Type 1 diabetes
Results from the body’s failure to produce insulin, the hormone that “unlocks” the cells of the body, allowing glucose to enter and fuel them. It is estimated that 5-10% of Americans who are diagnosed with diabetes have type 1 diabetes.

Type 2 diabetes
Results from insulin resistance (a condition in which the body fails to properly use insulin), combined with relative insulin deficiency. Most Americans who are diagnosed with diabetes have type 2 diabetes.

Medications for Type 2 Diabetes

Sulfonylureas:
- GLUCOTROL XL (Glipizide)
- AMARYL (Glimepiride)

Meglitinides:
- PRANDIN (Repaglinide)
- STARLIX (Nateglinide)

Biguanides:
- GLUCOPHAGE (Metformin)

Thiazolidinediones:
- ACTOS (Pioglitazone)
- ACTOPLUS MET (Pioglitazone/Metformin)
- AVANDIA (Rosiglitazone)
- AVANDAMET (Rosiglitazone/Metformin)

Other medications:
- KARELA and DIABECON

Gestational diabetes
Gestational diabetes affects about 4% of all pregnant women - about 135,000 cases in the United States each year.

Pre-diabetes
Pre-diabetes is a condition that occurs when a person’s blood glucose levels are higher than normal but not high enough for a diagnosis of type 2 diabetes. There are 54 million Americans who have pre-diabetes, in addition to the 20.8 million with diabetes.

Additional Information

Recently Diagnosed
You or someone you love has just been diagnosed with diabetes — chances are you have a million questions running through your head. This area of our Web site can help ease your fears and teach you more about living with diabetes or caring for someone with diabetes, and connect you with others affected by diabetes who will listen and share their own experiences.

Diabetes Symptoms
Often diabetes goes undiagnosed because many of its symptoms seem so harmless. Learn what they are in this section.

Diabetes Risk Test
More than 20 million Americans have diabetes — nearly one in three does not know it! Take our diabetes risk test to see if you are at risk for having diabetes. Diabetes is more common in African Americans, Latinos, Native Americans, Asian Americans and Pacific Islanders.

Diabetes Myths
Find the truth about some of the most common myths about diabetes.

The Genetics of Diabetes
You’ve probably wondered how you got diabetes. You may worry that your children will get it too. Unlike some traits, diabetes does not seem to be inherited in a simple pattern. Yet clearly, some people are born more likely to get diabetes than others.

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Calorie overload sends the brain haywire: study

October 4th, 2008

WASHINGTON (Reuters) - Overeating makes the brain go haywire, prompting a cascade of damage that may cause diabetes, heart disease and other ills, U.S. researchers reported on Thursday.

Eating too much appears to activate a usually dormant immune system pathway in the brain, sending out immune cells to attack and destroy invaders that are not there, Dongsheng Cai of the University of Wisconsin-Madison and colleagues found.

The finding, reported in the journal Cell, could help explain why obesity causes so many different diseases. It might also offer a way to prevent obesity itself.

“This pathway is usually present but inactive in the brain,” Cai said in a statement.

Obesity is a growing global problem, with 1.8 billion people estimated to be overweight or obese in 2007. Drugs marketed so far to fight obesity have only limited success and, often, severe side-effects.

Cai’s team worked in mice, seeking to explain studies that have shown that obesity causes chronic inflammation throughout the body. This inflammation is found in a range of diseases related to obesity, including heart disease and diabetes.

They homed in on a compound known as IKKbeta/NK-kappaB.

Immune cells such as macrophages and leukocytes use it but Cai’s team found it in the hypothalamus, a part of the brain linked with metabolism in mice and humans alike.

“The hypothalamus is the ‘headquarters’ for regulating energy,” they wrote.

They found high levels of the compound there but it was normally inactive.

When they fed mice a high-fat diet, it became extremely active. And when it was active, the body ignored signals from leptin, a hormone that normally helps regulate appetite, and insulin, which helps convert food into energy.

Stimulating IKKbeta/NK-kappaB made the mice eat more, while suppressing it made them eat less.

Cai believes his team has discovered a master switch for the diseases caused by overeating.

“Hypothalamic IKKb/NF-kB could underlie the entire family of modern diseases induced by overnutrition and obesity,” his team wrote.

Cai does not know why this compound would be in the brain and in the immune system but suspects it evolved long ago in primitive animals that do not have the same sophisticated immune system as modern animals, including mice and humans.

“Presumably it played some role to guide the immune defense,” Cai said in a telephone interview. “In today’s society, this pathway is mobilized by a different environmental challenge — overnutrition.”

“Knocking out” the gene using genetic engineering kept mice eating normally and prevented obesity. This cannot be done in people but Cai believes a drug, or even gene therapy, might work.

With gene therapy, a virus or other so-called vector is used to carry corrective DNA into the body, but the approach is still highly experimental.

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Analogue or human insulins OK for type 2 diabetes

October 4th, 2008

 

NEW YORK (Reuters Health) - People with type 2 diabetes who need insulin to control their blood glucose levels can choose either human insulin or a structurally similar synthetic version to do the job, a study shows.

“There is no difference between premixed human insulin and premixed insulin analogues,” Dr. Rehan Qayyum from Johns Hopkins Hospital, Baltimore, told Reuters Health.

Qayyum and colleagues reviewed clinical studies of the effectiveness and safety of premixed insulin analogues compared with other anti-diabetes agents in adults with type 2 diabetes.

Premixed insulin analogues provided tighter glucose control than long-acting insulin and non-insulin agents, according to the investigators’ report in the Annals of Internal Medicine. Premixed insulin analogues were comparable to premixed human insulin in lowering A1C levels, an indicator of relatively long-term glucose control.
The occurrence of episodes of too-low glucose levels, i.e., hypoglycemia, was similar with premixed insulin analogues and with premixed human insulin.

“I have found in my previous comparative research that the benefits of new treatments and interventions are often exaggerated by industry and academia (unfortunately),” Qayyum added.

“Studies with longer follow-up are needed to determine whether the effects observed early in treatment are sustainable long-term,” the team concludes.

SOURCE: Annals of Internal Medicine, online September 15, 2008.

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Birth risks differ for Asian-Caucasian couples

October 4th, 2008

NEW YORK (Reuters Health) - New research indicates that the rates of cesarean deliveries, gestational diabetes, and other pregnancy-related outcomes differ among Asian, Caucasian, and interracial Asian-Caucasian couples.

“Our study demonstrates that interracial Asian-Caucasian couples represent a population with distinct perinatal risks, with differing risks depending upon which parent is of Asian race,” the researchers state in the American Journal of Obstetrics and Gynecology.

The findings are based on a study of 868 Asian-Caucasian couples, 3226 Asian couples, and 5575 Caucasian couples who delivered at the Lucile Packard Children’s Hospital in Stanford, California, from 2000 to 2005.
Compared to Caucasian couples, Asian-Caucasian couples were 2.4- and 2.6-times more likely to be affected by gestational diabetes, depending on whether the mother was Caucasian or Asian, Dr. Michael J. Nystrom, from Stanford University Medical Center, and colleagues found.

The risk in Asian couples, however, was even higher at 4.7-times higher than in Caucasian couple,

The results also indicate that Caucasian couples had larger babies than the other groups. The average birthweight in Caucasian couples was 3400 grams, compared with the next highest weight, 3360 grams, which was seen in Asian-mother/Caucasian-father couples.

Compared with Asian couples, Asian-mother/Caucasian-father couples were the only ones to have an increased rate of cesarean delivery.

“Further research into interracial couples may she light onto the effects of genetics vs environment on perinatal outcomes,” the team concludes.

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